by Amy Hicks
The Cox Lab at the Jackson Laboratory is part of less than a handful of research groups worldwide working on a rare form of Spinal Muscular Atrophy called SMARD1. This video gives a basic introduction to this disease as well as an overview of the research goals of a postdoctoral researcher in the Cox Lab, Amy Hicks, who is studying the relationship between the heart and nerves in this devastating genetic disease.
• Learn more about SMARD from the NIH's Genetics Home Reference
• Find great resources and information about SMARD and other types of Spinal Muscular Atrophy from SMA News Today
• Identification of the Mouse Neuromuscular Degeneration Gene and Mapping of a Second Site Suppressor Allele. Cox et al 1998.
• Transgenic rescue of neurogenic atriphy in the nmd mouse reveals a role for Ighmbp2 in dilated cardiomyopathy. Maddatu et al 2004.
• Dilated cardiomyopathy in the nmd mouse: transgenic rescue and QTLs that improve cardiac function and survival. Maddatu et al 2005.