Gyrification: how the brain folds


Gyrification is the process occurring during the fetal stage that leads to the formation of the folds that appear on the surface of our brain. Because it can shed light on the functioning of the brain and some neurological diseases, understanding how and why these structures form is important. This led us to distinguish two complementary mechanisms that rule this phenomenon: biomechanics and genetically determined cellular processes. In this video, Thomas Perros summarizes these works and explanations to give a quick overview of the research on gyrification.


Thomas Perros is a student in the Cell Physics Master at the University of Strasbourg, France.


References:

[1]: Essen, D. "A tension-based theory of morphogenesis and compact wiring in the central nervous system."https://www.nature.com/articles/385313a0

[2]: K roenke CD, Bayly PV. "How Forces Fold the Cerebral Cortex." https://www.jneurosci.org/content/38/4/767

[3]: Van Essen DC. "A 2020 view of tension-based cortical morphogenesis." https://pubmed.ncbi.nlm.nih.gov/33323481/

[4]: Tallinen T., Chung J., Rousseau F. et al. "On the growth and form of cortical convolutions." https://www.nature.com/articles/nphys3632

[5]: Borrell V. "How Cells Fold the Cerebral Cortex." https://www.jneurosci.org/content/38/4/776

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